Stability of Antibiotics (upon reconstitution and dilution)

Antibiotics	Reconstitution		Dilution
	Diluent	Stability	Diluent	Stability
Ampicillin Na	SWFI	1 hour (RT)	PNSS	8 hours (CRT) 48 hours (REF)
			PlainLR	8 hours (CRT) 24 hours (REF)
			D5W	2 hours (CRT) 4 hours (REF)
Ampicillin-Sulbactam Na	SWFI	1 hour (RT)	PNSS	8 hours (CRT) 48 hours (REF)
			PlainLR	8 hours (CRT) 24 hours (REF)
			D5W	2 hours (CRT) 4 hours (REF)
Benzylpenicillin Na	SWFI, PNSS	3 days (REF)**	PNSS	3 days (REF)**
Cefazolin Na	SWFI	24 hours (CRT) 10 days (REF)	PNSS, D5W	24 hours (CRT) 10 days (REF)
Cefepime HCl	PNSS, D5W, D5NSS, D5LR	24 hours (CRT) 7 days (REF)	PNSS, D5W, D5NSS, D5LR	24 hours (CRT) 7 days (REF)
Cefotaxime Na	SWFI, PNSS, D5W	24 hours (CRT) 5 days (REF)	PNSS, D5W	24 hours (CRT) 5 days (REF)
Cefoxitin Na	SWFI, D5W, PNSS	6 hours (CRT) 7 days (REF)	D5W, D5NSS, PNSS	18 hours (CRT) 48 hours (REF)
Ceftazidime	SWFI	12 hours (CRT) 3 days (REF)	D5W, PNSS	12 hours (CRT) 3 days (REF)
Ceftriaxone Na	SWFI, PNSS, D5W, D5NSS	3 days (CRT) 10 days (REF)*	PNSS, D5W	3 days (CRT) 10 days (REF)*
Clindamycin PO4	PNSS, D5W	Administer as soon as possible, avoid refrigeration	PNSS, D5W	Administer as soon as possible, avoid refrigeration
Meropenem	SWFI	Immediate use is preferable 2 hours (CRT) 12 hours (REF)	PNSS	2 hours (CRT) 18 hours (REF)
Piperacillin-Tazobactam Na	SWFI, PNSS, D5W	24 hours (CRT) 48 hours (REF)	PNSS, D5W	24 hours (CRT) 48 hours (REF)

**Maintain refrigeration

*Selected preparations only, refer to the given drug literature if possible

Source: Gahart's Intravenous Medications